Podcast with Andrew Weisse: Beyond The Journey

Jill Sitnick
December 5, 2025
8:34 am

Podcast with Andrew Weisse: Beyond The Journey

How Psychedelics Help Us Grieve: Exploring Grief, Death, and the “After” with Andrew Weisse

What happens after the healing? What if the real transformation begins once the medicine wears off?

In this episode of The Psychedelic Scene Podcast, host Jill Sitnick sits down with Andrew Weisse, writer, speaker, and creator of a grief-centered psychedelic blog, to explore what happens when the journey is over… and life continues. From personal loss to mystical experiences with 5-MeO-DMT, this conversation unpacks grief, psychedelics, and how we show up for others after we’ve done our own inner work.

Let’s dive into the big questions raised in this compelling episode.

What Happens After the Psychedelic Journey?

While many psychedelic conversations focus on what happens during the trip, Jill and Andrew agree that the more important question is: What happens next?

“There’s an after. You achieve a certain goal… and then what?” – Jill Sitnick

Andrew shares that after a powerful first experience with 5-MeO-DMT (yes, he started with the “deep end”), he realized the real work was not in the peak experience—but in how it changed his relationships, his identity, and his understanding of service.

Who Is Andrew Weisse, and Why Does He Write About Psychedelics and Grief?

Andrew’s path began with unimaginable loss, as both of his siblings passed away. That grief launched him on a journey that took him from Wall Street to wellness, eventually leading to his blog about psychedelics, death, and the art of grieving in community.

“I started with 5-MeO-DMT. Not the entry-level, but that was the beginning of a spiritual reckoning.” – Andrew Weisse

His blog now explores how psychedelics impact our ability to connect—with ourselves, with others, and with the reality of death.

Andrew M. Weisse

How Do Psychedelics Help With Grief and Loss?

Andrew’s experiences—and many others like his—point to this: psychedelics often don’t “fix” grief. But they change how we relate to it.

“Some people say psychedelics help them accept death—not as an end, but as a transition.”

Andrew describes how his early experience with 5-MeO-DMT gave him a direct, visceral sense of being part of something larger—a mystical moment that made him reconsider his identity and pain.

This aligns with what many people in the psychedelic space experience: the medicine doesn’t erase grief, but it reframes it.

Andrew M. Weisse

What Are Better Entry Points Than 5-MeO-DMT?

Andrew jokes about his first journey being a “cautionary tale.” His advice now?

“Start with low to medium-dose psilocybin or even MDMA with your partner. 5-MeO is not where you begin.”

This grounded guidance matches Jill’s trauma-informed ethos: no one should dive into psychedelics without proper preparation. Not all substances are alike—and not everyone is ready for the most intense ones.

Andrew M. Weisse

What Does It Mean to Serve the Collective After Healing?

One of the deepest parts of this episode centers on how healing shifts us toward service.

Andrew reflects on the idea that once we’ve done some healing, the real responsibility becomes: How do we show up for others? How do we hold space for a community’s grief, not just our own?

“The deepest healing isn’t just personal—it’s about how we serve the collective.”

This resonates with the purpose behind Jill’s work—educating, preparing, and integrating others not just for one trip, but for the long-term impact.

Andrew M. Weisse

Key Takeaways

Psychedelics can open the door to processing grief but integration is where healing takes root.
Not all psychedelics are equal. 5-MeO-DMT is powerful and potentially overwhelming—better to start with MDMA or psilocybin.
Mystical experiences can reframe our relationship to death and identity.
After healing, the real journey is showing up for others—from a place of wholeness, not woundedness.